Arthrosamid® Treatment for Knee Osteoarthritis

arthrosamid box with syringe

Discover Arthrosamid® - Now Available at Sonoscope

Are you struggling with knee osteoarthritis? There’s a groundbreaking, non-surgical treatment now available in Hertfordshire at Sonoscope that is redefining treatment for patients living with knee pain.

Revolutionary Treatment for Knee Osteoarthritis

Knee osteoarthritis is the most common form of arthritis, affecting millions of people worldwide. While joint replacement surgery is effective, it is also a major invasive procedure with a lengthy recovery period. But now, there’s an alternative.

Introducing Arthrosamid®

Arthrosamid® is a non-biodegradable injectable polyacrylamide hydrogel (2.5% iPAAG) implant consisting of 2.5% cross-linked polyacrylamide and 97.5% water. It is administered via a simple, one-step procedure performed under local anaesthesia by a qualified physician, such as an orthopaedic surgeon or rheumatologist1 — ensuring you’re in and out of the clinic the same day. Arthrosamid® is proven to maintain a significant, long-lasting reduction in knee OA pain2,3— even five years post-treatment.2

Arthrosamid Treatment

Clinical Assessment

Consult

Diagnostic Ultrasound

Diagnostic scan

Ultrasound guided injection

Ultrasound guided injection

One stop Shop

"One Stop Clinic"

inforgarphic of arthrosamid timeline

How does Arthrosamid® work?

Arthrosamid® is the first and only permanent injectable implant that integrates with the knee’s synovial tissue,4 forming a scaffold that softens and increases tissue elasticity. This leads to decreased joint stiffness, reduced pain, and improved knee function.5,6,7

Proven Results

  • Over 20 years of research and development.9
  • Safe and effective6,8 for its intended use, even five years post-treatment.2
  • Around 1,200,000 syringes of 2.5% iPAAG have been made for human use.9

Speak to our specialist

Let's find the source of the pain

Contact us today and let's find the source of pain

What the expert(s) say?

Robert Mast BSc Physiotherapy HCPC, MCSP, PgCert Musculoskeletal Sonography, Non-Medical prescriber

For more information on the treatment please visit arthrosamid.com.

To book an appointment for Rob call 07999923844 or email info@sonoscope.co.uk.

Medications: 

Some people can be experiencing high levels of pain making it difficult for them to function and to sleep without waking at night. Nonsteroidal anti-inflammatory drugs such as naproxen, ibuprofen and many others, can be helpful to reduce high levels of pain. Unfortunately these drugs can cause side effects and are not suitable for some people with certain pre-existing medical conditions. Please speak to your GP to discuss.

Injection Therapy

When exercise therapy in addition with appropriate medications do not provide enough pain relief cortisone injection therapy can be considered as a next step.

Evidence states that ultrasound guided steroid injections are much more accurate than unguided steroid injections, as the needle placement can be monitored under ultrasound guidance.

There is a significant body of research indicating that ultrasound guided injections are not only safer but they also give longer lasting pain relief.

This means that the benefits are experienced sooner and the beneficial effects such as pain relief last longer.

Steroid Injection Therapy

Steroid injections have been used to manage pain in people with osteoarthritis for many years. It can be very effective to quickly reduce high levels of pain for a period of time. However it is very important to understand that this is a temporary measure. It should be seen that the pain relief from these injections would allow people to engage with exercise therapy which might otherwise not be possible due to the high levels of pain.

People have to be very cautious with repeat steroid injections as they generally will decline in effectiveness if repeated frequently. Also ongoing steroid injections will eventually cause significant side-effects and this is therefore not recommended.

Surgery

Generally speaking, the surgery is fairly invasive and involves either full or part knee joint replacement. Although there might be temporary benefit from an arthroscopic washout it generally lasts for months not much longer than a steroid or hyaluronic acid injection.

Knee joint replacement surgery is a relatively big procedure and people should consider the risks and potential complications of this surgery carefully. Also whilst it can be very effective the knee joint still is liable to deteriorate over time so therefore knee joint replacement surgery is not recommended for people who are relatively young as there will be a need to replace the joint after an average of 15 years following the first surgery.

Hyaluronic acid injections:

Hydaluronic acid injections are relatively new. They are a good alternative for steroid injections and are not associated with any significant side effects. The mechanism of action is that the hyaluronic acid, which is not a drug but a gel, provides a coat to the Joint surface which will make the joint surfaces more slippery and promote gliding. This in turn will reduce the irritation of the arthritic joint and reduce pain as well as swelling. This option is particularly beneficial for people who are concerned about side-effects from steroid injections or who have not had great benefit from steroid injections. Hyaluronic acid injections may not be beneficial for people with fairly advanced osteoarthritis.

Each case should be discussed with our expert team

Book Your Consultation in Hertfordshire

Downloadable Resources on Arthrosamid

References:

  1. Arthrosamid®, Instructions For Use. Release Date March 2022. 10082-003.
  2. Bliddal, H., et al. (2025) A Prospective Study of Polyacrylamide Hydrogel Injection for Knee Osteoarthritis: Results From 5 Years After Treatment. Presented at WCO-IOF-ESCEO 2025.
  3. Bliddal, H., et al. (2024) 3 year follow-up from a randomized controlled trial of intra-articular polyacrylamide hydrogel injection in subjects with knee osteoarthritis. Osteoarthritis and Cartilage. Vol 32 (6): 770-771.
  4. Christensen, L., et al. (2016). Histological Appearance of the Synovial Membrane after Treatment of Knee Osteoarthritis with Polyacrylamide Gel Injections: A Case Report. Journal of Arthritis. Vol 5: 217.
  5. Bliddal, H., et al. (2021) Polyacrylamide Hydrogel Injection for Knee Osteoarthritis: A 6 Months Prospective Study. J Orthop Res Ther. Vol 6 (2). 1188. ISSN 2575-8241.
  6. Bliddal, H., et al. (2024). Polyacrylamide gel versus hyaluronic acid for the treatment of knee osteoarthritis: a randomised controlled study. Clin Exp Rheumatol. Vol 42(9):1729-1735.
  7. Henriksen, M., et al. (2018). Intra-articular 2.5% polyacrylamide hydrogel for the treatment of knee osteoarthritis: an observational proof-of-concept cohort study. Clin Exp Rheumatol. Vol 36(6):1082-85. Epub 2018 Jul 18. PMID: 30148430.
  8. Bliddal, H., et al. (2024). Effectiveness and safety of polyacrylamide hydrogel injection for knee osteoarthritis: results from a 12-month follow up of an open-label study. J Orthop Surg Res. Vol 19: 274.
  9. Data on file.
Meet Rob Mast founder of Sonoscope Ultrasound

Meet Rob - Our Specialist Physiotherapist/ Sonographer

Rob is a specialist Extended Scope Physiotherapist with more than 20 years experience in managing complex musculoskeletal conditions.

He uses diagnostic ultrasound as an extension of his clinical skills.  He is an interventional sonographer in a busy radiology department of a central London Foundation Trust Hospital .

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